G6PD deficiency in malaria endemic areas of Nepal
نویسندگان
چکیده
منابع مشابه
Polymorphism analysis of malaria susceptibility biomarkers in G6PD deficiency patients
Abstract Background: Several studies suggested that some traits and polymorphisms in human genome such as G6PD deficiency and other genes have protective effects on susceptibility to malaria infection . Methods: In present study we investigated the prevalence of TNF [1] -244GgA, TNF [1] - 308 GgA,TNF [1] -238GgA, NOS2-954GgC, MBL54GgA, MBL 57GgA, MBL IVSI - 5 GgA polymorphisms and G6P...
متن کاملPrevalence of G6PD deficiency in selected populations from two previously high malaria endemic areas of Sri Lanka
Glucose-6-Phosphate Dehydrogenase (G6PD) enzyme deficiency is known to offer protection against malaria and an increased selection of mutant genes in malaria endemic regions is expected. However, anti-malarial drugs such as primaquine can cause haemolytic anaemia in persons with G6PD deficiency. We studied the extent of G6PD deficiency in selected persons attending Teaching Hospitals of Anuradh...
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BACKGROUND Patients infected by Plasmodium vivax or Plasmodium ovale suffer repeated clinical attacks without primaquine therapy against latent stages in liver. Primaquine causes seriously threatening acute hemolytic anemia in patients having inherited glucose-6-phosphate dehydrogenase (G6PD) deficiency. Access to safe primaquine therapy hinges upon the ability to confirm G6PD normal status. Ca...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2020
ISSN: 1475-2875
DOI: 10.1186/s12936-020-03359-6